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This guide lays out the framework necessary to host a High Performance Computing (HPC)-focused cyberattack tabletop exercise (TTX) so that organizations can begin to have these conversations around HPC security. The guide takes readers through an example tabletop exercise designed to assist stakeholders in discussing HPC security as an incident unfolds and establish common ground on actions that can be taken to improve the security of the HPC systems as well as develop incident response (IR) processes around HPC systems.